Jeff over at Coding Horror was talking about his new Image host Amazon s3 (Using Amazon S3 as an Image Hosting Service).  I like the service. The only problem with it I could find was Amazon does not provide any client side application to upload content.  Thanks to Jeff's post that has been solved check out S3Fox Organizer a nifty tool to manage the content sitting in the S3 cloud(did I mention its free?).  Also a comment on Jeff's site from John mentioned how to setup Virtual Hosting of Buckets for Amazon S3.

Update:

I mined a few more links off of the Comments on codding horror.

http://s3sync.net/wiki
S3Drive is a Windows application that lets you access the Amazon web space as a local network drive.